The potential antiepileptic activity of astaxanthin in epileptic rats treated with valproic acid

被引：13
作者：
Abdulqader, Yussra Ata Yaseen [1 ,2 ]
Kawy, Hala Salah Abdel [1 ]
Alkreathy, Huda Mohammed [1 ]
Rajeh, Nisreen Abdullah [3 ]
机构：
[1] King Abdulaziz Univ, Fac Med, Dept Pharmacol, Jeddah, Saudi Arabia
[2] King Abdullah Med Complex, Jeddah, Saudi Arabia
[3] King Abdulaziz Univ, Fac Med, Dept Anat, Jeddah, Saudi Arabia
来源：
SAUDI PHARMACEUTICAL JOURNAL | 2021年 / 29卷 / 05期
关键词：
Epilepsy; Valproic acid; Astaxanthin; Pentylenetetrazol; ROS; OXIDATIVE STRESS; PENTYLENETETRAZOLE; THERAPY; SEIZURE; MODELS; TISSUE; LIVER; MICE;
D O I：
10.1016/j.jsps.2021.04.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Objectives: Epilepsy is a neurological disease characterized by sudden, abnormal, and hyper- discharges in the central nervous system (CNS). Valproic acid (VPA) is commonly used as a broad-spectrum antiepileptic therapeutic. However, in many cases, patients develop resistance to VPA treatment due to overwhelming oxidative stress, which in turn might be a major catalyst for disease progression. Therefore, antioxidants can potentially become therapeutic agents by counteracting reactive oxygen species (ROS)-mediated damage. The present study is aimed to evaluate the potential antiepileptic effect of astaxanthin (ASTA) in pentylenetetrazol (PTZ) induced epileptic model rats that are chronically treated with VPA for 8 weeks. Method: Fifty-male Wistar rats were randomly divided into five groups: Non-PTZ group, PTZ, PTZ/VPA, PTZ/ASTA, and PTZ/VPA/ASTA treated groups. Results: PTZ/VPA treated group showed a neuroprotective effect with improvement in antioxidant levels, behavioral test, and histopathological changes induced by PTZ. VPA also exhibited an anti-inflammatory effect as its treatment resulted in the reduction of tumor necrosis factor-alpha (TNF-alpha). ASTA exhibited an anticonvulsant effect and enhanced anti-inflammatory effect as compared to VPA. During the combined therapy, ASTA potentiated the antiepileptic effect of the VPA by reducing the oxidative stress and TNF-alpha as well as increased the glutathione (GSH) levels. Also, there were substantial improvements in the behavioral and histopathological changes in the VPA/ASTA treated group as compared to the VPA treated group. Conclusion: ASTA could have an antiepileptic and anti-inflammatory effect by reducing ROS generation. Therefore, co-administration of both the therapeutics (VPA/ASTA) has a synergistic effect in treating epilepsy and could potentially minimize recurrence and/or exacerbation of seizures. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：418 / 426
页数：9
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