Potential Triazole-based Molecules for the Treatment of Neglected Diseases

被引：14

作者：

Mantoani, Susimaire Pedersoli ^{[1
]}

de Andrade, Peterson ^{[1
]}

Cantuaria Chierrito, Talita Perez ^{[1
]}

Figueredo, Andreza Silva ^{[1
]}

Carvalho, Ivone ^{[1
]}

机构：

[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

CURRENT MEDICINAL CHEMISTRY | 2019年 / 26卷 / 23期

基金：

巴西圣保罗研究基金会;

关键词：

Neglected diseases; triazoles; chagas disease; malaria; Leishmaniasis; tuberculosis; TRYPANOSOMA-CRUZI ACTIVITY; IN-VITRO; BIOLOGICAL EVALUATION; DRUG DISCOVERY; 1,3-DIPOLAR CYCLOADDITION; CLICK CHEMISTRY; CHAGAS-DISEASE; 1,2,3-TRIAZOLE DERIVATIVES; ANTIMYCOBACTERIAL AGENTS; LINKED CHALCONE;

D O I：

10.2174/0929867324666170727103901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to de- scribe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazole-based molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis.

引用

页码：4403 / 4434

页数：32

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