Neuropharmacological Effects of Quercetin: A Literature-Based Review

被引：110

作者：

Islam, Md. Shahazul ^{[1
]}

Quispe, Cristina ^{[2
]}

Hossain, Rajib ^{[1
]}

Islam, Muhammad Torequl ^{[1
]}

Al-Harrasi, Ahmed ^{[3
]}

Al-Rawahi, Ahmed ^{[3
]}

Martorell, Miquel ^{[4
]}

Mamurova, Assem ^{[5
]}

Seilkhan, Ainur ^{[6
,7
]}

Altybaeva, Nazgul ^{[8
]}

Abdullayeva, Bagila ^{[5
]}

Docea, Anca Oana ^{[9
]}

Calina, Daniela ^{[10
]}

Sharifi-Rad, Javad ^{[11
]}

机构：

[1] Bangabandhu Sheikh Mujibur Rahman Sci & Technol U, Fac Life Sci, Dept Pharm, Gopalganj, Bangladesh

[2] Univ Arturo Prat, Fac Ciencias Salud, Iquique, Chile

[3] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman

[4] Univ Concepcion, Dept Nutr & Dietet, Ctr Hlth Living, Fac Pharm, Concepcion, Chile

[5] Al Farabi Kazakh Natl Univ, Dept Biodivers Bioresources, Alma Ata, Kazakhstan

[6] Abai Kazakh Natl Pedag Univ, Educ program, Geog Environm & Serv Sect, Alma Ata, Kazakhstan

[7] Al Farabi Kazakh Natl Univ, Biomed Res Ctr, Alma Ata, Kazakhstan

[8] Al Farabi Kazakh Natl Univ, Dept Mol Biol & Genet, Alma Ata, Kazakhstan

[9] Univ Med & Pharm Craiova, Dept Toxicol, Craiova, Romania

[10] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova, Romania

[11] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

quercetin; neuropharmacological effects; neural damage; signaling pathways; mechanisms; neurodegenerative disorders; INDUCED OXIDATIVE STRESS; ALZHEIMERS-DISEASE; NEURODEGENERATIVE DISEASES; PARKINSONS-DISEASE; AMYLOID-BETA; PC12; CELLS; IN-SILICO; CAENORHABDITIS-ELEGANS; HYPERICUM-PERFORATUM; MOLECULAR-MECHANISMS;

D O I：

10.3389/fphar.2021.665031

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer's disease, Amyloid beta peptide, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

引用

页数：16

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