Breast cancer heterogeneity through the lens of single-cell analysis and spatial pathologies

被引：27

作者：

Zhao, Na ^{[1
]}

Rosen, Jeffrey M. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 82卷

关键词：

Breast cancer; Tumor heterogeneity; Single-cell; Spatial pathology; Tumor microenvironment; MAMMARY-GLAND DEVELOPMENT; MASS CYTOMETRY; INTRATUMOR HETEROGENEITY; GENE-EXPRESSION; IDENTIFIES HETEROGENEITY; EVOLUTION; THERAPY; IMMUNE; REVEALS; SEQ;

D O I：

10.1016/j.semcancer.2021.07.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer ecosystems are composed of complex cell types, including tumor, stromal and immune cells, each of which can assume diverse phenotypes. Both the heterogeneous composition and spatially distinct tumor microenvironment impact breast cancer progression, treatment response and therapeutic resistance. Thus, a deeper understanding of breast cancer heterogeneity may help facilitate the development of novel therapies and improve outcomes for patients. The advent of paradigm shifting single-cell analysis and spatial pathologies allows for a comprehensive analysis of the tumor ecosystem as well as the interactions between its components at unprecedented resolution. In this review, we discuss the insights gained through single-cell analysis and spatial pathologies on breast cancer heterogeneity.

引用

页码：3 / 10

页数：8

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