Functionalized Biodegradable Nano- and Microspheres for Medical Applications

被引：7

作者：

Slomkowski, Stanislaw ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, PL-90363 Lodz, Poland

来源：

MACROMOLECULAR SYMPOSIA | 2010年 / 288卷

关键词：

drug delivery; encapsulation; microspheres; nanoparticles; polylactide; poly(epsilon-caprolactone); DRUG-RELEASE BEHAVIOR; DISPERSION POLYMERIZATION; POLYLACTIDE MICROSPHERES; ANTIBACTERIAL PROPERTIES; ACID) MICROSPHERES; ETHYLENE-GLYCOL; NANOPARTICLES; POLY(EPSILON-CAPROLACTONE); MECHANISM; DELIVERY;

D O I：

10.1002/masy.201050216

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This minireview describes strategies for preparation of biodegradable (from polylactides, and poly(epsilon-caprolactone) and from their derivatives) nano- and microspheres for medical applications, in particular for drug delivery. In addition to standard methods of particles' formation by emulsification of polymer solution in water-miscible organic solvent with subsequent solvent evaporation or extraction there are described methods of particles formation by self assembly of polymer macromolecules, by dialysis of polymer solutions in organic water-miscible solvents carried on against water and by dispersion ring-opening polymerization of heterocyclic monomers. Strategies for encapsulation of bioactive compounds into nano- and microspheres are presented.

引用

页码：121 / 129

页数：9

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