Salicylate induces reactive oxygen species and reduces ultraviolet C susceptibility in Staphylococcus aureus

被引：2

作者：

Cai, Jia-Yi ^{[1
]}

Wang, Yuan-yuan ^{[1
,2
]}

Ma, Kai ^{[1
]}

Hou, Yong-Na ^{[1
]}

Yao, Guo-Dong ^{[3
]}

Hayashi, Toshihiko ^{[1
]}

Itoh, Kikuji ^{[4
]}

Tashiro, Shin-ichi ^{[5
]}

Onodera, Satoshi ^{[6
]}

Ikejima, Takashi ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, China Japan Res Inst Med & Pharmaceut Sci, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China

[2] Shanghai FrontHlth Pharmaceut Technol Co, Dept Drug Discover & Dev, Shanghai 201203, Peoples R China

[3] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[4] Japan SLC Inc, Biochem Ctr, Shizuoka 4311103, Japan

[5] Kyoto Prefectural Univ Med, Dept Med Educ & Primary Care, Kyoto 6028566, Japan

[6] Showa Pharmaceut Univ, Dept Clin & Pharmaceut Sci, Tokyo 1948543, Japan

来源：

FEMS MICROBIOLOGY LETTERS | 2018年 / 365卷 / 08期

关键词：

cell death; reactive oxygen species; salicylate; Staphylococcus aureus; ultraviolet C; ESCHERICHIA-COLI; ANTIBIOTIC-RESISTANCE; OXIDATIVE STRESS; ACTIVATION; EXPRESSION; INDUCTION; INCREASES; PHENOTYPE; RADIATION; SYSTEM;

D O I：

10.1093/femsle/fny056

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study demonstrates that growth of Staphylococcus aureus in the presence of salicylate reduces ultraviolet C (UVC)-induced cell death and increases the generation of reactive oxygen species (ROS). In addition, compounds that scavenge ROS (N-acetylcysteine, glutathione, catalase and superoxide dismutase) reverse the increased UVC survival induced by growth in the presence of salicylate, while ROS donors (tert-butylhydroperoxide, H2O2 and NaClO) enhance survival of salicylate challenged cultures. Collectively, these findings suggest that ROS production induced by growth in the presence of salicylate protects S. aureus from UVC-induced cell death.

引用

页数：5

共 30 条

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