A new synthetic approach and in vitro antimicrobial evaluation of novel imidazole incorporated 4-thiazolidinone motifs

被引：18

作者：

Desai, N. C. ^{[1
]}

Joshi, V. V. ^{[1
]}

Rajpara, K. M. ^{[1
]}

Makwana, Atul H. ^{[1
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2017年 / 10卷

关键词：

Imidazole; 4-Thiazolidinone; Antibacterial activity; Antifungal activity; MIC; THIAZOLIDINONE DERIVATIVES; INHIBITOR; POTENT; ANTAGONISTS; CHEMISTRY; CP-060S; KINASE; AGENTS;

D O I：

10.1016/j.arabjc.2012.10.020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is our ongoing effort to search new bio-active molecules and as a part of this, several chemical processes like condensation, cycloaddition were carried out to furnish 2-((1-(4-(4-(arylidene)- 5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl) phenyl) ethylidene) hydrazono) thiazolidin-4-ones (4a-o). All compounds were characterized by IR, H-1 NMR, C-13 NMR and mass spectra. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger and Aspergillus clavatus by bioassay namely serial broth dilution. On the basis of statistical analysis, it was observed that these compounds showed significant co-relation. The synthesized compounds showed potent antimicrobial activity against test microorganisms. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S589 / S599

页数：11

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