The importance of precision medicine in modern molecular oncology

被引:7
作者
Wang, Yuanli [1 ]
Zheng, Dawu [1 ]
机构
[1] First Peoples Hosp Qinzhou, Precis Med Lab, Qinzhou, Guangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
application; next-generation sequencing; precision medicine; targeted therapy; tumor diagnosis; GENERATION SEQUENCING NGS; CELL LUNG-CANCER; MUTATIONS; DNA; AMPLIFICATION; EXPRESSION; CRIZOTINIB; FUSION;
D O I
10.1111/cge.13998
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
With the rapid development of modern medical technology, information data modeling has been gradually applied to clinical diagnosis and treatment. Precision medicine is an important approach that focuses on individual patients in terms of their own characteristics, genomic information, proteomics and even social environments. Genome-wide high-throughput technologies, including DNA-seq, RNA-seq, exosome-seq horizontal ellipsis , contribute enormous amounts of molecular data to aid in diagnosis and analysis. Here, we review the developmental history of different next-generation sequencing platforms, introduce their applications in different tumor diagnosis and therapy, and further discuss the remaining challenges in precision medicine.
引用
收藏
页码:248 / 257
页数:10
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