Hormonal regulation of male germ cell development

被引：168
作者：
Ruwanpura, Saleela M. [1 ]
McLachlan, Robert I. [1 ]
Meachem, Sarah J. [1 ]
机构：
[1] Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia
来源：
JOURNAL OF ENDOCRINOLOGY | 2010年 / 205卷 / 02期
基金：
英国医学研究理事会;
关键词：
FOLLICLE-STIMULATING-HORMONE; GONADOTROPIN-RELEASING-HORMONE; MESSENGER-RIBONUCLEIC-ACID; ELEMENT-BINDING PROTEIN; SERTOLI-CELL; LUTEINIZING-HORMONE; ANDROGEN RECEPTOR; ADULT-RATS; IN-VITRO; TESTOSTERONE WITHDRAWAL;
D O I：
10.1677/JOE-10-0025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Over the past five decades, intense research using various animal models, innovative technologies notably genetically modified mice and wider use of stereological methods, unique agents to modulate hormones, genomic and proteomic techniques, have identified the cellular sites of spermatogenesis, that are regulated by FSH and testosterone. It has been established that testosterone is essential for spermatogenesis, and also FSH plays a valuable role. Therefore understanding the basic mechanisms by which hormones govern germ cell progression are important steps towards improved understating of fertility regulation in health diseases. Journal of Endocrinology (2010) 205, 117-131
引用
收藏
页码：117 / 131
页数：15
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