Prevention of Gastric Cancer: Eradication of Helicobacter pylori and Beyond

被引：57

作者：

Tsukamoto, Tetsuya ^{[1
]}

Nakagawa, Mitsuru ^{[1
]}

Kiriyama, Yuka ^{[1
]}

Toyoda, Takeshi ^{[2
]}

Cao, Xueyuan ^{[3
]}

机构：

[1] Fujita Hlth Univ, Dept Diagnost Pathol, Sch Med, Toyoake, Aichi 4701192, Japan

[2] Natl Inst Hlth Sci, Div Pathol, Tokyo 1588501, Japan

[3] Jilin Univ, Dept Gastr & Colorectal Surg, Changchun 130000, Jilin, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 08期

关键词：

Helicobacter pylori; chronic atrophic gastritis; intestinal metaplasia; eradication; chemoprevention; INFECTED MONGOLIAN GERBILS; METHYL-N-NITROSOUREA; GLANDULAR STOMACH CARCINOGENESIS; SMALL ANIMAL-MODEL; TERM-FOLLOW-UP; SELECTIVE CYCLOOXYGENASE-2 INHIBITOR; UNIDENTIFIED CURVED BACILLI; RANDOMIZED CONTROLLED-TRIAL; ACTIVE CHRONIC GASTRITIS; INTESTINAL METAPLASIA;

D O I：

10.3390/ijms18081699

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.

引用

页数：16

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