Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62

被引：75

作者：

Arai, T ^{[1
]}

Nonaka, T

Hasegawa, M

Akiyama, H

Yoshida, M

Hashizume, Y

Tsuchiya, K

Oda, T

Ikeda, K

机构：

[1] Psychiat Res Inst Tokyo, Dept Psychogeriat, Setagaya Ku, Tokyo 1568585, Japan

[2] Psychiat Res Inst Tokyo, Dept Mol Neurobiol, Setagaya Ku, Tokyo 1568585, Japan

[3] Aichi Med Univ, Inst Med Sci Aging, Dept Neuropathol, Aichi 4801195, Japan

[4] Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan

[5] Natl Shimofusa Mental Hosp, Dept Neuropsychiat, Chiba 2660007, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 342卷 / 1-2期

关键词：

ubiquitin; tau; oligodendrocyte; astrocyte; aggregate; immunohistochemistry;

D O I：

10.1016/S0304-3940(03)00216-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the immunoreactivity of p62 in five cases of frontotemporal dementia (FTD) with ubiquitin-positive, tau-negative inclusions. Only one case had clinical features suggestive of motor neuron disease (MND). In all cases, ubiquitin-positive neuronal inclusions and neurites in the hippocampal region and cerebral neocortex were immunohistochemically positive for p62. Moreover, in the temporal region of a case of FTD with MND, many oligodendrocytes and some astrocytes were positive for p62. These results suggest that the degenerative process involves p62 in FTD and that the process takes place not only in neurons but also in glial cells. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

共 20 条

[1] Different variants of frontotemporal dementia: A neuropathological and immunohistochemical study [J].

Bergmann, M ;

Kuchelmeister, K ;

Schmid, KW ;

Kretzschmar, HA ;

Schroder, R .

ACTA NEUROPATHOLOGICA, 1996, 92 (02) :170-179

[2] Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type [J].

Forno, LS ;

Langston, JW ;

Herrick, MK ;

Wilson, JD ;

Murayama, S .

ACTA NEUROPATHOLOGICA, 2002, 103 (06) :599-606

[3] Structure and functional properties of the ubiquitin binding protein p62 [J].

Geetha, T ;

Wooten, MW .

FEBS LETTERS, 2002, 512 (1-3) :19-24

[4] Glial tau pathology in neurodegenerative diseases: Their nature and comparison with neuronal tangles [J].

Ikeda, K ;

Akiyama, H ;

Arai, T ;

Nishimura, T .

NEUROBIOLOGY OF AGING, 1998, 19 (01) :S85-S91

[5] Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia [J].

Ikeda, K ;

Akiyama, H ;

Arai, T ;

Ueno, H ;

Tsuchiya, K ;

Kosaka, K .

ACTA NEUROPATHOLOGICA, 2002, 104 (01) :21-28

[6] Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies [J].

Iseki, E ;

Li, F ;

Odawara, T ;

Hino, H ;

Suzuki, K ;

Kosaka, K ;

Akiyama, H ;

Ikeda, K ;

Kato, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 159 (02) :194-201

[7] Motor neurone disease-inclusion dementia [J].

Jackson, M ;

Lennox, G ;

Lowe, J .

NEURODEGENERATION, 1996, 5 (04) :339-350

[8] Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions [J].

Kertesz, A ;

Kawarai, T ;

Rogaeva, E ;

St George-Hyslop, P ;

Poorkaj, P ;

Bird, TD ;

Munoz, DG .

NEUROLOGY, 2000, 54 (04) :818-827

[9] Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation [J].

Kuusisto, E ;

Salminen, A ;

Alafuzoff, I .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2002, 28 (03) :228-237

[10] Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies [J].

Kuusisto, E ;

Salminen, A ;

Alafuzoff, I .

NEUROREPORT, 2001, 12 (10) :2085-2090

← 1 2 →