Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke

被引：5

作者：

Noori, Tayebeh ^{[1
]}

Shirooie, Samira ^{[1
]}

Sureda, Antoni ^{[2
,3
,4
]}

Sobarzo-Sanchez, Eduardo ^{[5
]}

Dehpour, Ahmad Reza ^{[6
,7
]}

Saldias, Marianela ^{[5
]}

Akkol, Esra Kupeli ^{[8
]}

机构：

[1] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran

[2] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress NUCOX, Palma De Mallorca 07122, Balearic Island, Spain

[3] Univ Balearic Isl, Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07122, Balearic Island, Spain

[4] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain

[5] Univ Cent Chile, Fac Ciencias Salud, Inst Invest & Postgrad, Santiago, Chile

[6] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran

[7] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[8] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

来源：

NEUROCHEMICAL RESEARCH | 2022年 / 47卷 / 08期

关键词：

The death-associated protein kinase 1 (DAPK1); Stroke Natural product; Neurological disorders; PROTEIN-KINASE; 1; CEREBRAL-ISCHEMIA REPERFUSION; TUMOR-SUPPRESSOR DAPK; ISCHEMIA/REPERFUSION INJURY; SIGNALING PATHWAY; CELL-DEATH; RAT MODEL; CANCER CHEMOPREVENTION; DNA METHYLTRANSFERASES; AUTOPHAGY ACTIVATION;

D O I：

10.1007/s11064-022-03628-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repositioning blocked arteries using thrombolytic agents or endovascular therapy are the most effective treatments for stroke. However, restoring circulation after thrombolysis can cause fatal edema or intracranial hemorrhage, and worsen brain damage in a process known as ischemia-reperfusion injury. Therefore, there is a pressing need to find and develop more effective treatments for stroke. In the past, the first choice of treatment was based on natural compounds. Natural compounds are able to reduce the symptoms and reduce various diseases including stroke that attract the attention of the pharmaceutical industry. Nowadays, as a result of the numerous studies carried out in the field of herbal medicine, many useful and valuable effects of plants have been identified. The death-associated protein kinase (DAPK) family is one of the vital families of serine/threonine kinases involved in the regulation of some biological functions in human cells. DAPK1 is the most studied kinase within the DAPKs family as it is involved in neuronal and recovery processes. Dysregulation of DAPK1 in the brain is involved in the developing neurological diseases such as stroke. Natural products can function in a variety of ways, including reducing cerebral edema, reducing brain endothelial cell death, and inhibiting TNF alpha and interleukin-1 beta (IL-1 beta) through regulating the DAPK1 signal against stroke. Due to the role of DAPK1 in neurological disorders, the aim of this article was to investigate the role of DAPK1 in stroke and its modulation by natural compounds. [GRAPHICS] .

引用

页码：2142 / 2157

页数：16