Nucleic Acids with a Six-Membered 'Carbohydrate' Mimic in the Backbone

被引：66
作者：
Herdewijn, Piet [1 ]
机构：
[1] Rega Inst, Med Chem Lab, B-3000 Louvain, Belgium
来源：
CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 01期
关键词：
BASE-PAIRING PROPERTIES; ALTRITOL-MODIFIED SIRNAS; ANTIVIRAL ACTIVITY; CONFORMATIONAL-ANALYSIS; BUILDING-BLOCKS; 1,5-ANHYDROHEXITOL NUCLEOTIDES; OLIGONUCLEOTIDE SYNTHESIS; HOMO-DNA; RNASE-H; 2,4-DIDEOXY-BETA-D-ERYTHRO-HEXOPYRANOSYL NUCLEOSIDES;
D O I：
10.1002/cbdv.200900185
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Starting from pyranose nucleic acids, several series of modified nucleic acids with a six-membered carbohydrate moiety (mimic) have been synthesized and analyzed over a period of 20 years, and this work is summarized here. The process starts with structural and conformational considerations, followed by synthetic efforts and a structural analysis, and ends up with a biological confirmation of the concept, demonstrating that these modified nucleic acids represent very valuable tools in chemistry and biology.
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页码：1 / 59
页数：59
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