The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function

被引：14

作者：

Chung, Sooyoung ^{[1
,2
]}

Kim, Il Hwan ^{[3
]}

Lee, Dongmin ^{[4
]}

Park, Kyungjoon ^{[5
]}

Kim, Joo Yeon ^{[1
,4
]}

Lee, Yeon Kyung ^{[6
]}

Kim, Eun Joo ^{[7
]}

Lee, Hyun Woo ^{[1
,4
]}

Choi, June-seek ^{[6
]}

Son, Gi Hoon ^{[1
]}

Sun, Woong ^{[1
,4
]}

Shin, Ki Soon ^{[6
]}

Kim, Hyun ^{[1
,4
]}

机构：

[1] Korea Univ, Coll Med, Brain Korea PLUS 21, Dept Biomed Sci, Seoul 136705, South Korea

[2] Ewha Womans Univ, Scranton Coll, Dept Brain & Cognit Sci, Seoul 03760, South Korea

[3] Duke Univ, Dept Cell Biol, Sch Med, Durham, NC 27710 USA

[4] Korea Univ, Coll Med, Dept Anat, Seoul 136705, South Korea

[5] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Dept Biol, Seoul 130701, South Korea

[6] Korea Univ, Dept Psychol, Seoul 136701, South Korea

[7] Univ Washington, Dept Psychol, Seattle, WA 98195 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

新加坡国家研究基金会;

关键词：

ANXIETY; FEAR; CIRCUITS; STRESS; IDENTIFICATION; EXCITABILITY; EXPRESSION; MEMORY; PKA;

D O I：

10.1038/srep23757

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a molecule enriched in the brain and neurons that regulates intracellular calcium levels via signaling through the inositol trisphosphate receptor. In the present study, we found that IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. Genetic abrogation of IP3K-A altered amygdala gene expression, particularly in genes involved in key intracellular signaling pathways and genes mediating fear-and anxiety-related behaviors. In agreement with the changes in amygdala gene expression profiles, IP3K-A knockout (KO) mice displayed more robust responses to aversive stimuli and spent less time in the open arms of the elevated plus maze, indicating high levels of innate fear and anxiety. In addition to behavioral phenotypes, decreased excitatory and inhibitory postsynaptic current and reduced c-Fos immunoreactivity in the CeA of IP3K-A KO mice suggest that IP3K-A has a profound influence on the basal activities of fear-and anxiety-mediating amygdala circuitry. In conclusion, our findings collectively demonstrate that IP3K-A plays an important role in regulating affective states by modulating metabotropic receptor signaling pathways and neural activity in the amygdala.

引用

页数：10

共 37 条

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