Identifying statin-associated autoimmune necrotizing myopathy

被引：21

作者：

Albayda, Jemima ^{[1
]}

Christopher-Stine, Lisa ^{[2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med & Instructor Med, Div Rheumatol, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Johns Hopkins Myositis Ctr, Div Rheumatol, Baltimore, MD 21224 USA

[3] Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2014年 / 81卷 / 12期

关键词：

ANTI-3-HYDROXY-3-METHYLGLUTARYL-COENZYME; THERAPY; SAFETY;

D O I：

10.3949/ccjm.81a.13158

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.

引用

收藏

页码：736 / 741

页数：6

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