Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers

被引：18

作者：

Lee, Jung Goo ^{[1
,2
,3
]}

Woo, Young Sup ^{[4
]}

Park, Sung Woo ^{[2
,3
,5
]}

Seog, Dae-Hyun ^{[6
,7
]}

Seo, Mi Kyoung ^{[2
]}

Bahk, Won-Myong

机构：

[1] Inje Univ, Haeundae Paik Hosp, Dept Psychiat, Coll Med, Busan, South Korea

[2] Inje Univ, Paik Inst Clin Res, Busan, South Korea

[3] Inje Univ, Grad Sch, Dept Hlth Sci & Technol, Busan, South Korea

[4] Catholica Univ Korea, Dept Psychiat, Coll Med, Seoul, South Korea

[5] Inje Univ, Coll Med, Dept Convergence Biomed Sci, Busan, South Korea

[6] Inje Univ, Coll Med, Dept Biochem, Busan, South Korea

[7] Inje Univ, Dementia & Neurodegenerat Dis Res Ctr, Coll Med, Busan, South Korea

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2022年 / 20卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Bipolar disorder; Drug therapy; Neurobiology; PROTEIN-KINASE-C; GLYCOGEN-SYNTHASE KINASE-3; SIGNAL-TRANSDUCTION PATHWAYS; POSTMORTEM BRAIN; GENE-EXPRESSION; MONONUCLEAR LEUKOCYTES; MOLECULAR-MECHANISMS; BIOGENIC-AMINE; CA2+ RESPONSE; PLASMA GABA;

D O I：

10.9758/cpn.2022.20.2.228

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bipolar disorder is a mental illness that causes extreme mood swings and has a chronic course. However, the mechanism by which mood episodes with completely opposite characteristics appear repeatedly, or a mixture of symptoms appears, in patients with bipolar disorder remains unknown. Therefore, mood stabilizers are indicated only for single mood episodes, such as manic episodes and depressive episodes, and no true mood-stabilizing drugs effective for treating both manic and depressive episodes currently exist. Therefore, in this review, therapeutic targets that facilitate the development of mood stabilizers were examined by reviewing the current understanding of the neuromolecular etiology of bipolar disorder.

引用

页码：228 / 239

页数：12

共 107 条

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