Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder

被引:31
作者
Wang, Yan-yu [1 ,2 ,3 ]
Wang, Yi [1 ]
Zou, Ying-min [1 ,3 ]
Ni, Ke [1 ,3 ,4 ]
Tian, Xue [2 ]
Sun, Hong-wei [2 ]
Lui, Simon S. Y. [1 ,5 ]
Cheung, Eric F. C. [5 ]
Suckling, John [6 ,7 ]
Chan, Raymond C. K. [1 ,3 ]
机构
[1] Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
[2] Weifang Med Univ, Dept Psychol, Weifang 261053, Shandong, Peoples R China
[3] Univ Chinese Acad Sci, Dept Psychol, Beijing 100048, Peoples R China
[4] Mental Hlth Ctr Qiqihar City, Qiqihar 161006, Heilongjiang, Peoples R China
[5] Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
[6] Univ Cambridge, Dept Psychiat, Cambridge CB2 0SZ, England
[7] Cambridgeshire & Peterborough NHS Trust, Cambridge CB2 0SZ, England
基金
中国国家自然科学基金;
关键词
Theory of mind; Cross-diagnostic; Schizophrenia; Major depressive disorder; Bipolar disorder; Network analysis; SOCIAL COGNITION; 1ST-DEGREE RELATIVES; PSYCHOTIC FEATURES; NEGATIVE SYMPTOMS; NETWORK ANALYSIS; RATING-SCALE; ASSOCIATIONS; COMORBIDITY; PREVALENCE; MODELS;
D O I
10.1016/j.schres.2017.11.003
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly investigated. Methods: We recruited 35 participants with schizophrenia (SCZ), 35 with bipolar disorder (BD), 35 with major depressive disorder (MDD), and 35 healthy controls in this study. All participants were matched in age, gender proportion and IQ estimates. The Yoni task, capturing both the cognitive and affective components of ToM at the first- and second-order level was administered. Repeated-measure ANOVA and MANOVA were conducted to compare the group differences in ToM performance. A network was then constructed with ToM performances, psychotic and depressive symptoms, and executive function as nodes exploring the clinical correlates of ToM. Results: Overall, ToM impairments were observed in all patient groups compared with healthy controls, with patients with SCZ performing worse than those with BD. In second-order conditions, patients with SCZ and MDD showed deficits in both cognitive and affective conditions, while patients with BD performed significantly poorer in cognitive conditions. Network analysis showed that second-order affective ToM performance was associated with psychotic and depressive symptoms as well as executive dysfunction, while second-order affective ToM performance and negative symptoms showed relatively high centrality in the network. Conclusions: Patients with SCZ, MDD and BD exhibited different types and severity of impairments in ToM subcomponents. Impairment in higher-order affective ToM appears to be closely related to clinical symptoms in both psychotic and affective disorders. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:349 / 356
页数:8
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