Netrin-1 in cancer: Potential biomarker and therapeutic target?

被引：36
作者：
Kefeli, Umut [1 ]
Kefeli, Aysegul Ucuncu [2 ]
Cabuk, Devrim [1 ]
Isik, Ulas [1 ]
Sonkaya, Alper [1 ]
Acikgoz, Ozgur [1 ]
Ozden, Ercan [1 ]
Uygun, Kazim [1 ]
机构：
[1] Kocaeli Univ, Dept Med Oncol, Sch Med, TR-41380 Kocaeli, Turkey
[2] Kocaeli State Hosp, Dept Radiat Oncol, Kocaeli, Turkey
来源：
TUMOR BIOLOGY | 2017年 / 39卷 / 04期
关键词：
Netrin-1; cancer; biomarker; therapeutic; target; dependence receptors; CELL-DEATH; DEPENDENCE RECEPTORS; SIGNAL-TRANSDUCTION; NEURONAL GUIDANCE; SURVIVAL FACTOR; DCC; ANGIOGENESIS; EXPRESSION; UNC5H; ACTS;
D O I：
10.1177/1010428317698388
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Netrin-1, a laminin-related protein, is known to be involved in the nervous system development. Recently, Netrin-1's involvement in other processes such as cell adhesion, motility, proliferation, and differentiation that are important for the development of epithelial tissues has been described. In addition, Netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated-5 homolog, have been linked to apoptosis and angiogenesis. Since these properties are essential for tumor development, Netrin-1 and its receptors have been reported to promote tumorigenesis in many types of cancers. Here, we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers.
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页数：7
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