Determination of polar pharmaceuticals in sewage water of Greece by gas chromatography-mass spectrometry

被引：146

作者：

Koutsouba, V

Heberer, T

Fuhrmann, B

Schmidt-Baumler, K

Tsipi, D ^{[1
]}

Hiskia, A

机构：

[1] Inst Phys Chem, Natl Ctr Sci Res, Athens 15310, Greece

[2] Pesticide Residues Lab, Gen Chem State Lab, Athens 11521, Greece

[3] Tech Univ Berlin, Inst Food Chem, D-13355 Berlin, Germany

来源：

CHEMOSPHERE | 2003年 / 51卷 / 02期

关键词：

drug residues; new environmental contaminants; diclofenac;

D O I：

10.1016/S0045-6535(02)00819-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Sewage influents and effluents of different urban areas of Greece, were analyzed for polar pharmaceutical residues, used in human medicine. Drugs investigated were the anti-inflammatory drugs diclofenac and ibuprofen, the metabolite of the drugs clofibrates used as blood lipid regulators, clofibric acid and the analgesics phenazone and propyphenazone. Analysis was carried out using capillary gas chromatography-mass spectrometry with selected ion monitoring. The method used was involved solid phase extraction (C-18) and derivatization with pentafluorobenzyl bromide. Diclofenac was detected in every sewage effluent sample. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：69 / 75

页数：7

共 28 条

[1]

Ahel M., 2001, ACS Symp Ser, V791, P100, DOI DOI 10.1021/BK-2001-

[2] Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea [J].