Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation

被引：27
作者：
Zuniga, Mary C. [1 ]
White, Sharla L. Powell [2 ,3 ]
Zhou, Wei [1 ,2 ,3 ]
机构：
[1] VA Palo Alto Hlth Care Syst, Surg Serv, Palo Alto, CA USA
[2] Stanford Univ, Sch Med, Div Vasc Surg, Stanford, CA 94304 USA
[3] Stanford Univ, Sch Med, Cardiovasc Inst, Stanford, CA 94304 USA
来源：
VASCULAR MEDICINE | 2014年 / 19卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Atherosclerosis; co-culture; macrophage; smooth muscle cell; inflammation; COLONY-STIMULATING FACTOR; LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; MATRIX METALLOPROTEINASES; MONOCYTE TRANSMIGRATION; SUBENDOTHELIAL SPACE; SUBSTRATE STIFFNESS; MOUSE MODELS; CROSS-TALK; MIGRATION;
D O I：
10.1177/1358863X14550542
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Atherosclerotic cardiovascular disease has been acknowledged as a chronic inflammatory condition. Monocytes and macrophages lead the inflammatory pathology of atherosclerosis whereas changes in atheromatous plaque thickness and matrix composition are attributed to vascular smooth muscle cells. Because these cell types are key players in atherosclerosis progression, it is crucial to utilize a reliable system to investigate their interaction. In vitro co-culture systems are useful platforms to study specific molecular mechanisms between cells. This review aims to summarize the various co-culture models that have been developed to investigate vascular smooth muscle cell and monocyte/macrophage interactions, focusing on the monocyte/macrophage effects on vascular smooth muscle cell function.
引用
收藏
页码：394 / 406
页数：13
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