Abietane diterpenoids from Caryopteris incana (Thunb.) Miq.

被引：1

作者：

Zhao, Sen-Miao ^{[1
]}

Chou, Gui-Xin ^{[1
]}

Yang, Qing-Shan ^{[2
]}

Wang, Wei ^{[1
]}

Zhou, Jian-Li ^{[2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China

[2] Anhui Univ Tradit Chinese Med, Coll Pharm, Hefei 230031, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 14期

关键词：

PEPTIDASE-IV INHIBITORS; X CLANDONENSIS; CLERODENDRUM-MANDARINORUM; CRYPTOMERIA-JAPONICA; ALPHA-GLUCOSIDASE; AERIAL PARTS; ROOTS; CONSTITUENTS; TERPENOIDS; CELLS;

D O I：

10.1039/c6ob00139d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Twelve new diterpenes, caryopincaolide A-L (1-4, 11-12, 16-19, 27-28), together with twenty-eight known diterpenes, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1D and 2D NMR, IR, X-ray crystal diffraction and mass spectroscopic data, as well as ECD calculations. All compounds were tested for in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory activity, with compounds 3, 4, 28, 29, and 40 exhibiting DPP-IV inhibitory effects with IC50 values ranging from 54.2 to 228.9 mu M. Compounds 1, 3 and 4 also showed potent activity toward the inhibition of the growth of human cancer cells and 1 can induce apoptosis in Hey and A-549 cells.

引用

页码：3510 / 3520

页数：11

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