Two New Lignans from Lycopodium japonicum Thunb.

被引：1

作者：

Ren, Qin ^{[1
,2
]}

Zou, Zhenxing ^{[2
]}

Liu, Yang ^{[1
]}

Chen, Xi ^{[2
]}

Xu, Kangping ^{[2
]}

Tan, Guishan ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2019年 / 13卷 / 06期

关键词：

Lycopodium japonicum; lignans; ECD calculation; CONSTITUENTS; ALKALOIDS; TRITERPENOIDS;

D O I：

10.25135/rnp.126.19.03.1205

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new lignans, named lycojaponicumoside A (1) and B (2), together with four known compounds (3-6) were isolated from the n-BuOH extract of Lycopodium japonicum. Their structures were elucidated on the basis of extensive spectroscopic methods, especially various NMR techniques, HRESIMS and circular dichroism (CD). The absolute configuration of compound 1 was established by the calculation of electronic circular dichroism (ECD) curves. All of the compounds were evaluated for their cytotoxic activities against A549 and HepG2 human cancer cell lines, but those compounds did not exhibit cytotoxicity.

引用

页码：468 / 474

页数：7

共 19 条

[1]

Chinese Pharmacopoeia Commission, 2010, PHARM PEOPL REP CH 1

[2] Terpenoids and Norlignans from Metasequoia glyptostroboides [J].

Dong, Liao-Bin ;

He, Juan ;

Wang, Yuan-Yuan ;

Wu, Xing-De ;

Deng, Xu ;

Pan, Zheng-Hong ;

Xu, Gang ;

Peng, Li-Yan ;

Zhao, Yu ;

Li, Yan ;

Gong, Xun ;

Zhao, Qin-Shi .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (02) :234-239

[3] Lycopodine-Type Alkaloids from Lycopodium japonicum [J].

He J. ;

Wu X.-D. ;

Liu F. ;

Liu Y.-C. ;

Peng L.-Y. ;

Zhao Y. ;

Cheng X. ;

Luo H.-R. ;

Zhao Q.-S. .

Natural Products and Bioprospecting, 2014, 4 (4) :213-219

[4] Abscisic acid related compounds and lignans in prunes (Prunus domestica L.) and their oxygen radical absorbance capacity (ORAC) [J].

Kikuzaki, H ;

Kayano, S ;

Fukutsuka, N ;

Aoki, A ;

Kasamatsu, K ;

Yamasaki, Y ;

Mitani, T ;

Nakatani, N .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (02) :344-349

[5] Antitumor and antiinflammatory constituents from Celtis sinensis [J].

Kim, DK ;

Lim, JP ;

Kim, JW ;

Park, HW ;

Eun, JS .

ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (01) :39-43

[6] Lignan constituents from Chloranthus japonicus Sieb. [J].

Kuang, Hai-xue ;

Xia, Yong-gang ;

Yang, Bing-you ;

Wang, Qiu-hong ;

Lue, Shao-wa .

ARCHIVES OF PHARMACAL RESEARCH, 2009, 32 (03) :329-334

[7] 3',4-DI-O-METHYLCEDRUSIN - SYNTHESIS, RESOLUTION AND ABSOLUTE-CONFIGURATION [J].

LEMIERE, G ;

GAO, M ;

DEGROOT, A ;

DOMMISSE, R ;

LEPOIVRE, J ;

PIETERS, L ;

BUSS, V .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (13) :1775-1779

[8] Japonicumins A-D:: Four new compounds from Lycopodium japonicum [J].

Li, Xiao-Li ;

Zhao, Yu ;

Cheng, Xiao ;

Tu, Lin ;

Peng, Li-Yan ;

Xu, Gang ;

Zhao, Qin-Shi .

HELVETICA CHIMICA ACTA, 2006, 89 (07) :1467-1473

[9] Phenolics from Leontopodium leontopodioides inhibiting nitric oxide production [J].

Li, Xin ;

Luo, Jian-Guang ;

Wang, Xiao-Bing ;

Luo, Jun ;

Wang, Jun-Song ;

Kong, Ling-Yi .

FITOTERAPIA, 2012, 83 (05) :883-887

[10] Neolignans from the seeds of Prunus tomentosa (Rosaceae) and their chemotaxonomic interest [J].

Liu, Qing-Bo ;

Huang, Xiao-Xiao ;

Yan, Xin-Jia ;

Bai, Ming ;

Yu, Li-Hong ;

Hu, Chong ;

Zhu, Tao ;

Li, Ling-Zhi ;

Song, Shao-Jiang .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2014, 55 :236-240

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