Recruitment of presynaptic vesicles and facilitation of transmitter release

被引：0
作者：
Bykhovskaia, Maria [1 ]
机构：
[1] Lehigh Univ, Dept Biol Sci, Bethlehem, PA 18015 USA
来源：
NEUROCOMPUTING | 2007年 / 70卷 / 10-12期
基金：
美国国家卫生研究院;
关键词：
synaptic transmission; neuronal secretion; Monte-Carlo simulation; calcium; vesicle priming;
D O I：
10.1016/j.neucom.2006.10.112
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
Facilitation, an enhancement of neuronal secretion by repetitive stimulation, is due to an increase in the number of vesicles that fuse with the presynaptic membrane and release neurotransmitter in response to an action potential. We performed Monte-Carlo simulation of calcium-dependent priming and release of synaptic vesicles and simulated facilitation of transmitter release. The model incorporated the pools of docked, primed, and released vesicles and stochastic calcium-dependent transitions between these pools. The model was validated by comparison of the time-course of transmitter release, its variability, and the magnitude of facilitation with electrophysiology measurements of transmitter release at the lobster neuromuscular synapse. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：1689 / 1694
页数：6
相关论文
共 32 条
  • [1] Munc13-1 is essential for fusion competence of glutamatergic synoptic vesicles
    Augustin, I
    Rosenmund, C
    Südhof, TC
    Brose, N
    [J]. NATURE, 1999, 400 (6743) : 457 - 461
  • [2] The probability of quantal secretion near a single calcium channel of an active zone
    Bennett, MR
    Farnell, L
    Gibson, WG
    [J]. BIOPHYSICAL JOURNAL, 2000, 78 (05) : 2201 - 2221
  • [3] The probability of quantal secretion within an array of calcium channels of an active zone
    Bennett, MR
    Farnell, L
    Gibson, WG
    [J]. BIOPHYSICAL JOURNAL, 2000, 78 (05) : 2222 - 2240
  • [4] Single-domain/bound calcium hypothesis of transmitter release and facilitation
    Bertram, R
    Sherman, A
    Stanley, EF
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) : 1919 - 1931
  • [5] Modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release
    Bertram, R
    Smith, GD
    Sherman, A
    [J]. BIOPHYSICAL JOURNAL, 1999, 76 (02) : 735 - 750
  • [6] RESIDUAL FREE CALCIUM IS NOT RESPONSIBLE FOR FACILITATION OF NEUROTRANSMITTER RELEASE
    BLUNDON, JA
    WRIGHT, SN
    BRODWICK, MS
    BITTNER, GD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) : 9388 - 9392
  • [7] Stochastic modeling of facilitated neurosecretion
    Bykhovskaia, M
    Worden, MK
    Hackett, JT
    [J]. JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2000, 8 (02) : 113 - 126
  • [8] Bykhovskaia M, 2004, NEUROCOMPUTING, V58, P469, DOI 10.1016/j.neucom.2004.01.083
  • [9] Hyperosmolarity reduces facilitation by a Ca2+ independent mechanism at the lobster neuromuscular junction:: possible depletion of the releasable pool
    Bykhovskaia, M
    Polagaeva, E
    Hackett, JT
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2001, 537 (01): : 179 - 190
  • [10] Mechanisms underlying different facilitation forms at the lobster neuromuscular synapse
    Bykhovskala, M
    Polagaeva, E
    Hackett, JI
    [J]. BRAIN RESEARCH, 2004, 1019 (1-2) : 10 - 21
1234