T Cell Polarization at the Virological Synapse

被引：19

作者：

Jolly, Clare ^{[1
]}

机构：

[1] UCL, Div Infect & Immun, MRC Ctr Med Mol Virol, London W1T 4JF, England

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 06期

基金：

英国医学研究理事会;

关键词：

HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1 ENVELOPE GLYCOPROTEIN; MICROTUBULE-ORGANIZING CENTER; CHEDIAK-HIGASHI-SYNDROME; GP41 CYTOPLASMIC TAIL; TYROSINE-BASED SIGNAL; MEMBRANE-LIPID RAFTS; NATURAL-KILLER-CELLS; SPLENIC B-CELLS; IMMUNOLOGICAL SYNAPSE;

D O I：

10.3390/v2061261

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cell-to-cell spread of HIV-1 between CD4(+) T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.

引用

页码：1261 / 1278

页数：18

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