Increased micronucleus frequency after oral administration of cadmium in dogs

被引：6

作者：

Donmez-Altuntas, Hamiyet ^{[1
]}

Hamurcu, Zuhal

Liman, Narin

Demirtas, Halil

Imamoglu, Nalan

机构：

[1] Erciyes Univ, Fac Med, Dept Med Biol, Kayseri, Turkey

[2] Erciyes Univ, Dept Histol & Embryol, Kayseri, Turkey

[3] Erciyes Univ, Fac Vet, Kayseri, Turkey

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2006年 / 112卷 / 03期

关键词：

cadmium; cadmium oxide; dogs; feed; micronucleus;

D O I：

10.1385/BTER:112:3:241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cadmium (Cd) is a toxic heavy metal that has been classified as a human carcinogen by the International Agency for Research on Cancer. The genotoxic effects of cadmium oxide (CdO) were investigated in cultured dog lymphocytes after a short-term oral CdO administration by the micronucleus (MN) test. The dogs were given 10 mg CdO/kg body weight per day for 3 and 28 d, respectively group I (n = 7) and group II (n = 6). Blood samples were collected at the beginning of feeding and at 4 and 29 d after Cd administration and cultured for 72 h. Whereas no significant increase in the MN frequency in group I was observed (p = 0.398), a significant MN induction with CdO was found in group II (p = 0.028) when compared with initial MN frequencies of dogs in both groups. Our results suggest that CdO might be directly and/or indirectly genotoxic after a monthly oral administration of CdO in dogs.

引用

页码：241 / 246

页数：6

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