Inhibitory Activity of Diacylglycerol Acyltransferase by Glabrol Isolated from the Roots of Licorice

被引：20

作者：

Choi, Jung Ho ^{[2
]}

Choi, Ji Na ^{[1
]}

Lee, Sung Yoon ^{[1
]}

Lee, Sung Jae ^{[2
]}

Kim, Koanhoi ^{[3
]}

Kim, Young Kook ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Immune Modulator Res Ctr, Cheongwon 363883, South Korea

[2] Jeonnam Inst Nat Resources Res, Jangheung 529851, South Korea

[3] Pusan Natl Univ, Sch Med, Yangsan 626870, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 02期

关键词：

Acyl-coenzyme A: diacylglycerol acyltransferase; Licorice; Obesity; Type; 2; diabetes; Isoprenyl flavonoid; IN-VITRO; IDENTIFICATION; FLAVONOIDS; RESISTANCE; EXTRACT; DGAT;

D O I：

10.1007/s12272-010-0208-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acyl-coenzyme A: diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes triglyceride synthesis in the glycerol phosphate pathway. It has relations with the excess supply and accumulation of triglycerides. Therefore, DGAT inhibitors may act as a potential therapy for obesity and type 2 diabetes. Five flavonoids were isolated from the ethanol extracts of licorice roots, using an in vitro DGAT inhibitory assay. One isoprenyl flavonoid showed most potential inhibition of DGAT on five flavonoids (1-5). On the basis of spectral evidences, the compound was identified as glabrol (5). Compound 5 inhibited rat liver microsomal DGAT activity with an IC50 value of 8.0 mu M, but the IC50 value for four flavonoids (1-4) was more than 100 mu M. In addition, glabrol showed a noncompetitive type of inhibition against DGAT. These data suggest that potential therapy for the treatment in obesity and type 2 diabetes patients by licorice roots might be related with its DGAT inhibitory effect.

引用

页码：237 / 242

页数：6

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