Cytotoxic dibenzocyclooctadiene lignans from Kadsura coccinea

被引：27

作者：

Zhao, Qing-Jie ^{[1
]}

Song, Yan ^{[2
]}

Chen, Hai-Sheng ^{[3
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Organ Chem, Shanghai 200433, Peoples R China

[2] 455 Hosp Peoples Liberat Army, Dept Pharm, Shanghai 200052, Peoples R China

[3] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2014年 / 37卷 / 11期

关键词：

Kadsura coccinea; Schisandraceae; Dibenzocyclooctadiene lignans; Cytotoxic activity; CONSTITUENTS;

D O I：

10.1007/s12272-013-0186-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new dibenzocyclooctadiene lignans, kadusurain A-C (1-3), together with two known compounds kadsuphilin A (4) and B (5), were isolated from an EtOAc fraction of the 80 % acetone extract of Kadsura coccinea (Lem.) A. C. Smith. Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy. Anti-proliferative effect of isolated compounds was evaluated against four human tumor cell lines (A549, HCT116, HL-60, and HepG2), and it was found that compound 1 exhibited significant antiproliferative effects with IC50 values ranging from 1.05 to 12.56 mu g/ml.

引用

页码：1375 / 1379

页数：5

共 13 条

[1]

Hu X., 1999, ZHONG HUA BEN CAO, P895

[2]

IKEYA Y, 1979, CHEM PHARM BULL, V27, P1383

[3] KADSULIGNANS-L-N, 3 DIBENZOCYCLOOCTADIENE LIGNANS FROM KADSURA-COCCINEA [J].

LIU, JS ;

LI, L .

PHYTOCHEMISTRY, 1995, 38 (01) :241-245

[4]

LIU JS, 1992, PHYTOCHEMISTRY, V31, P957, DOI 10.1016/0031-9422(92)80047-I

[5] SCHISANTHERINS L-O AND ACETYLSCHISANTHERIN-L FROM KADSURA-COCCINEA [J].

LIU, JS ;

LI, L .

PHYTOCHEMISTRY, 1993, 32 (05) :1293-1296

[6] DETECTION OF ACTIVATED LYMPHOCYTE SUBSETS BY FLUORESCENCE AND MTT STAINING [J].

SCHAUER, U ;

KROLIKOWSKI, I ;

RIEGER, CHL .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 116 (02) :221-227

[7] C18 dibenzocyclooctadiene lignans from Kadsura philippinensis [J].

Shen, Ya-Ching ;

Liaw, Chia-Ching ;

Cheng, Yuan-Bin ;

Ahmed, Atallah F. ;

Lai, Mei-Chou ;

Liou, Shorong-Shii ;

Wu, Tian-Shung ;

Kuo, Yao-Haur ;

Lin, Yu-Chi .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (06) :963-966

[8] Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase [J].

Sun, HD ;

Qiu, SX ;

Lin, LZ ;

Wang, ZY ;

Lin, ZW ;

Pengsuparp, T ;

Pezzuto, JM ;

Fong, HHS ;

Cordell, GA ;

Farnsworth, NR .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (05) :525-527

[9] KADSULACTONE AND KADSUDILACTONE, 2 NEW TRITERPENOID LACTONES FROM KADSURA SPECIES [J].

TAN, R ;

XUE, H ;

LI, LN .

PLANTA MEDICA, 1991, 57 (01) :87-88

[10]

Wang LY, 2003, CHEM PHARM BULL, V51, P935, DOI 10.1248/cpb.51.935

← 1 2 →