Biomarkers in heart failure with preserved ejection fraction

被引：44
作者：
Meijers, W. C. [1 ]
van der Velde, A. R. [1 ]
de Boer, R. A. [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
来源：
NETHERLANDS HEART JOURNAL | 2016年 / 24卷 / 04期
关键词：
Heart failure; Preserved ejection fraction; Biomarkers; Natriuretic peptides; Diagnosis; Prognosis; BRAIN NATRIURETIC PEPTIDE; GROWTH-DIFFERENTIATION FACTOR-15; DIASTOLIC DYSFUNCTION; NT-PROBNP; EXERCISE CAPACITY; PROGNOSTIC VALUE; I-PRESERVE; PHOSPHODIESTERASE-5; INHIBITION; BODY-COMPOSITION; CLINICAL STATUS;
D O I：
10.1007/s12471-016-0817-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Biomarkers are widely used and studied in heart failure. Most studies have described the utility and performance of biomarkers in sub-studies of randomised clinical trials, where the vast majority of the patients suffered from heart failure with reduced ejection fraction (HFrEF), and not with preserved ejection fraction (HFpEF). As a result, there is a scarcity of data describing the levels, dynamics, clinical and biochemical correlates, and biology of biomarkers in patients suffering from HFpEF, whereas HFpEF is in fact a very frequent clinical entity. This article discusses the value of different biomarkers in HFpEF. We describe various aspects of natriuretic peptide measurements in HFpEF patients, with a focus on diagnosis, prognosis and the risk prediction of developing heart failure. Further, we will discuss several emerging biomarkers such as galectin-3 and suppression of tumorigenicity 2, and recently discovered ones such as growth differentiation factor-15 and syndecan-1.
引用
收藏
页码：252 / 258
页数：7
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