Comparison of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for diagnosis of latent tuberculosis in haemodialysis (HD) patients: a meta-analysis of κ estimates

被引：9

作者：

Ayubi, E. ^{[1
,2
,3
]}

Doosti-Irani, A. ^{[4
]}

Moghaddam, A. Sanjari ^{[5
]}

Khazaei, S. ^{[2
,4
]}

Mansori, K. ^{[6
,7
]}

Safiri, S. ^{[8
]}

Sani, M. ^{[9
]}

Mostafavi, E. ^{[3
,10
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran

[3] Pasteur Inst Iran, Dept Epidemiol & Biostat, Tehran, Iran

[4] Hamadan Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Hamadan, Iran

[5] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran

[6] Kurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Sanandaj, Iran

[7] Iran Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran

[8] Maragheh Univ Med Sci, Sch Nursing & Midwifery, Dept Publ Hlth, Managerial Epidemiol Res Ctr, Maragheh, Iran

[9] Zabol Univ Med Sci, Sch Med, Zabol, Iran

[10] Pasteur Inst Iran, Res Ctr Emerging & Reemerging Infect Dis, Tehran, Iran

来源：

EPIDEMIOLOGY AND INFECTION | 2017年 / 145卷 / 09期

关键词：

Haemodialysis patients; interferon-gamma release tests; kappa statistic; meta-analysis; tuberculin skin test; GAMMA RELEASE ASSAY; STAGE RENAL-DISEASE; INFECTION; UTILITY; RISK;

D O I：

10.1017/S0950268817000334

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Diagnosis of latent tuberculosis infection (LTBI) is a concern in haemodialysis (HD) patients. Many studies have compared QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for detecting LTBI and reported the kappa statistic of agreement between QFT-GIT and TST in HD patients. The present study aimed to systematically review this literature and conduct meta-analysis of individual studies that estimated the kappa between QFT-GIT with TST among HD patients. All relevant published studies that were available as full-text were obtained by searching Medline (1950), Web of Sciences (1945), Scopus (1973) through May 2016. The kappa was re-estimated from the individual studies and pooled using random effect meta-analysis. Subgroup analysis and meta-regression were applied to evaluate the effect of Bacillus Calmette-Guerin (BCG) vaccination, TST cut-off points, quality of studies, sample size and age on variation of kappa estimate. Eight studies involving 901 HD patients were included in meta-analysis. The pooled kappa estimate was 0.28 (I-2 = 18.4%, P = 0.239, 95% confidence intervals 0.22-0.34). The discordance of TST-/QFT-GIT+ was more than TST+/QFT-GIT-. History of BCG vaccination, TST cut-off points and age are related to variation of. estimates. TST and QFT-GIT are not comparable in detecting LTBI in HD patients. The higher TST-/QFT-GIT+ ratio compared with TST +/QFT-GIT-ratio, may indicate the superiority of QFT-GIT over TST for detection LTBI in HD patients.

引用

页码：1824 / 1833

页数：10

共 35 条

[1] Comparison of interferon gamma release assay & tuberculin skin tests for diagnosis of latent tuberculosis in patients on maintenance haemodialysis [J].