Immunosurveillance of Candida albicans commensalism by the adaptive immune system

被引:24
作者
Swidergall, Marc [1 ,2 ,3 ]
LeibundGut-Landmann, Salome [4 ,5 ]
机构
[1] Harbor UCLA Med Ctr, Div Infect Dis, Torrance, CA USA
[2] Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Torrance, CA USA
[3] UCLA, David Geffen Sch Med, Los Angeles, CA 90095 USA
[4] Univ Zurich, Vetsuisse Fac, Tect Immunol, Zurich, Switzerland
[5] Univ Zurich, Inst Expt Immunol, Zurich, Switzerland
基金
瑞士国家科学基金会;
关键词
ANTI-SACCHAROMYCES-CEREVISIAE; CHRONIC MUCOCUTANEOUS CANDIDIASIS; VAGINAL CANDIDIASIS; ANTIFUNGAL IMMUNITY; FUNGAL DYSBIOSIS; ANTIBODIES ASCA; CROHNS-DISEASE; GUT MICROBIOTA; HOST-DEFENSE; B-CELLS;
D O I
10.1038/s41385-022-00536-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease.
引用
收藏
页码:829 / 836
页数:8
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