I2 -Catalyzed Three-Component Consecutive Reaction for the Synthesis of 3-Aroylimidazo[1,2-a]-N-Heterocycles

被引：29

作者：

Zhang, Yi ^{[1
,2
,3
]}

Chen, Rener ^{[1
,2
]}

Wang, Zhiming ^{[1
,2
]}

Wang, Lei ^{[1
,2
]}

Ma, Yongmin ^{[1
,2
,3
]}

机构：

[1] Taizhou Univ, Inst Adv Studies, Taizhou 318000, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China

[3] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 09期

关键词：

DIMETHYL-SULFOXIDE; AMINOOXYGENATION; 2-AMINOPYRIDINES; DERIVATIVES; IMIDAZO; KETONES; ALKYNES; ACCESS;

D O I：

10.1021/acs.joc.1c00023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient one-pot, three-component reaction has been developed for the synthesis of 3-aroylimidazo[1,2-a]-N-hetero-cycles from aryl ketones and 2-amino-N-heterocycles using dimethyl sulfoxide as a methylene donor. The reaction proceeds smoothly catalyzed by I-2 in the presence of K2S2O8 and affords the desired products in moderate to good yields. This protocol offers significant superiority in accessing biologically active 3-aroylimidazo[1,2-a]-N-heterocycles with various substitution patterns.

引用

页码：6239 / 6246

页数：8

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