Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?

被引：12

作者：

Devi, S. Mohana ^{[1
]}

Mahalaxmi, I ^{[2
]}

Kaavya, J. ^{[2
]}

Chinnkulandhai, V ^{[3
]}

Balachandar, V ^{[4
]}

机构：

[1] Sankara Nethralaya, SN ONGC Dept Genet & Mol Biol, Vis Res Fdn, 41-18 Coll Rd, Chennai 600006, Tamil Nadu, India

[2] Avinashilingam Univ Women, Avinashilingam Inst Home Sci & Higher Educ Women, Dept Zool, Coimbatore 641046, Tamil Nadu, India

[3] DrNGP Arts & Sci Coll, Dept Biochem, Coimbatore 641046, Tamil Nadu, India

[4] Bharathiar Univ, Dept Human Genet & Mol Biol, Human Mol Genet & Stem Cells Lab, Coimbatore 641046, Tamil Nadu, India

来源：

GENES & DISEASES | 2021年 / 8卷 / 03期

关键词：

Age-related macular degeneration (AMD); Diabetic Retinopathy (DR); Epigenetics; Gene expression; MITOCHONDRIAL TRANSCRIPTION FACTOR; METABOLIC MEMORY; DNA METHYLATION; CONTINUED PROGRESSION; OXIDATIVE STRESS; IL17RC PROMOTER; POTENTIAL ROLE; COMPLICATIONS; MECHANISMS; HYPOMETHYLATION;

D O I：

10.1016/j.gendis.2020.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review, we try to examine the role of DNA methylation and histone modification in Age related macular degeneration (AMD) and Diabetic Retinopathy (DR), its vascular complications and recent progress. Given the complex nature of AMD and DR, it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

引用

页码：279 / 286

页数：8

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