General and Efficient Copper-Catalyzed Three-Component Coupling Reaction towards Imidazoheterocycles: One-Pot Synthesis of Alpidem and Zolpidem

被引：392

作者：

Chernyak, Natalia ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 15期

关键词：

cyclization; heterocycles; homogeneous catalysis; imidazopyridines; multicomponent reactions; PERIPHERAL BENZODIAZEPINE-RECEPTOR; MULTICOMPONENT SYNTHESIS; ALDEHYDES; ALKYNES; PROPARGYLAMINES; AFFINITY; LIGANDS; BINDING; AMINES;

D O I：

10.1002/anie.200907291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Three is not a crowd: A method for the construction of Imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and Zolpidem (see scheme). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2743 / 2746

页数：4

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