Efect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury

被引：46

作者：

Yao, Yao

Cui, Yi ^{[2
]}

Zhao, Yannan ^{[3
]}

Xiao, Zhifeng ^{[3
]}

Li, Xing ^{[3
]}

Han, Sufang ^{[3
]}

Chen, Bing ^{[3
]}

Fang, Yongxiang ^{[4
]}

Wang, Piao ^{[5
]}

Pan, Juli ^{[1
]}

Dai, Jianwu ^{[3
]}

机构：

[1] Capital Med Univ, Sch Stomatol, Dept Prosthodont, Beijing 100050, Peoples R China

[2] Reprod & GeneticNatl Res Inst Family Planning, Beijing 100081, Peoples R China

[3] Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China

[4] CAAS, State Key Lab Vet Etiol Biol, Key Lab Vet Publ Hlth, Lanzhou Vet Res Inst,Minist Agr, Lanzhou 730046, Gansu, Peoples R China

[5] Capital Med Univ, Sch Stomatol, Dept Oral & Maxillofacial Plast & Trauma Surg, Beijing 100050, Peoples R China

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2018年 / 106卷 / 06期

关键词：

sciatic nerve injury; longitudinally oriented collagen conduit; NGF; nerve regeneration; NEUROTROPHIC FACTORS; REPAIR; STRATEGIES; SCAFFOLDS; PERSPECTIVES; NEUROPATHY; RECEPTOR; THERAPY; TUBE; RATS;

D O I：

10.1002/jbm.b.34020

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The research on artificial nerve conduits has become a focus of study in peripheral nerve reconstruction so as a possible replacement for the treatment of autologous nerve grafts in clinics. In this study, we used longitudinally oriented collagen conduit (LOCC) combined with nerve growth factor (NGF) to reconstruct long distance of sciatic nerve defects (35 mm) in adult dog model. The long term follow-up evaluation demonstrated that the LOCC/NGF conduit allowed functional and morphological nerve regeneration at the transection site of the injured sciatic nerve. Furthermore, the functional study confirmed that when NGF was loaded onto LOCC it promoted a better recovery of regenerated axons than LOCC alone. The gastrocnemius muscle mass in the LOCC/NGF group was significantly greater than in the LOCC alone group. The results indicated that when LOCC conduit combined with NGF it would provide a preferential environment for sciatic nerve regeneration. (C) 2017 Wiley Periodicals, Inc.

引用

页码：2131 / 2139

页数：9

共 38 条

[21] Neuroprotective effects of ultrasound-guided nerve growth factor injections after sciatic nerve injury [J].