Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango

被引：21

作者：

Baldwin, Michael R.

Kim, Jung-Ja P.

Barbieri, Joseph T.

机构：

[1] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 01期

关键词：

D O I：

10.1038/nsmb0107-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two independent crystal structure analyses have resolved the detailed interactions between botulinum neurotoxin serotype B and its neuronal receptor, synaptotagmin. The studies show how the toxin binds synaptotagmin and, along with previously determined interactions with the ganglioside G(T1b), a coreceptor, explain the toxin's extreme toxicity and tropism for neurons.

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页码：9 / 10

页数：3

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