Recent developments in chiral analysis of β-blocker drugs by capillary electromigration techniques

被引：14
|
作者：
Ma, Yanhua [1 ,2 ]
Zhang, Huige [1 ,2 ]
Chen, Hongli [1 ,2 ]
Chen, Xingguo [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China
[3] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou, Peoples R China
来源：
ELECTROPHORESIS | 2014年 / 35卷 / 23期
基金：
中国国家自然科学基金;
关键词：
beta-Blocker drugs; Chiral analysis; Chiral selector; Detection sensitivity; Online sample preconcentration; LIQUID-CHROMATOGRAPHIC ENANTIOSEPARATION; BASIC DRUGS; ENANTIOMERIC SEPARATION; ELECTROPHORESIS; SELECTOR; CE; PROPRANOLOL; ELECTROCHROMATOGRAPHY; CYCLODEXTRIN; SENSITIVITY;
D O I：
10.1002/elps.201400363
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The latest developments in chiral analysis of beta-blocker drugs by capillary electromigration techniques are reviewed in this article. Following the previous review by Aturki et al. [Electrophoresis 2011, 32, 2602-2628], this review includes the papers published during the period from January 2011 to December 2013. During this time, some novel chiral selectors were reported and applied to improve the enantioseparation of beta-blocker drugs and structurally related compounds. These chiral selectors include CDs and their derivatives, macrocyclic antibiotics, tartrate complexs, the monolithic molecularly imprinted polymer, and the polymeric surfactants. In addition, this article summarizes the methodological improvements for enhancing sensitivity in chiral analysis of beta-blockers and structurally related compounds by CE. The involved authors described the use of online sample preconcentration techniques to increase the detection sensitivity in the enantiomeric analysis of a broad range of samples.
引用
收藏
页码：3345 / 3354
页数：10
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