Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

被引：14
作者：
Cao, H. L. [1 ,2 ,3 ]
Dong, Y. X. [4 ]
Aied, A. [4 ]
Zhao, T. Y. [4 ]
Chen, X. [1 ,2 ,3 ]
Wang, W. X. [4 ]
Pandit, A. [5 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
[3] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr, Shanghai 200237, Peoples R China
[4] Univ Coll Dublin, Charles Inst Dermatol, Dublin, Ireland
[5] Natl Univ Ireland, Network Excellence Funct Biomat, Galway, Ireland
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 98期
关键词：
VINYL OLIGOMER COMBINATION; ANTICANCER DRUGS; DELIVERY-SYSTEMS; BLOCK-COPOLYMER; PDMAEMA; THERAPY; DESIGN;
D O I：
10.1039/c4cc06728b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.
引用
收藏
页码：15565 / 15568
页数：4
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