Anti-proliferative and Apoptotic Activity Against an Acute Myeloid Leukemia Cell Line by Constituents from Ficus benghalensis

被引：0
|
作者：
Hassan, Heba Ali [1 ]
Allam, Ahmed E. [2 ]
Alaaeldin, Rania [3 ]
Mustafa, Muhamad [4 ,5 ]
Mohyeldin, Reham H. [6 ]
Shimizu, Kuniyoshi [7 ]
Abdelwahab, Sayed F. [8 ]
Desouky, Samar Y. [9 ]
Mohamed, Khaled M. [10 ]
Kamel, Mohamed S. [9 ,11 ]
机构：
[1] Sohag Univ, Fac Pharm, Dept Pharmacognosy, Sohag 82524, Egypt
[2] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71524, Egypt
[3] Deraya Univ, Fac Pharm, Dept Biochem, New Minia City 61111, Egypt
[4] Univ Montpellier, Inst Biomol Max Mousseron, Montpellier, France
[5] Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia City 61111, Egypt
[6] Deraya Univ, Fac Pharm, Dept Pharmacol & Toxicol, New Minia City 61111, Egypt
[7] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Dept Agroenvironm Sci, Fukuoka 8190395, Japan
[8] Taif Univ, Taif Coll Pharm, Dept Pharmaceut & Ind Pharm, POB 11099, Taif 21944, Saudi Arabia
[9] Minia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya 61519, Egypt
[10] Fayoum Univ, Fac Pharm, Dept Pharmacognosy, Al Fayyum 63514, Egypt
[11] Deraya Univ, Fac Pharm, Dept Pharmacognosy, New Minia City 61111, Egypt
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2022年 / 32卷 / 04期
关键词：
Annexin V assay; Cytotoxic; Cell cycle analysis; Cell viability assay; Pyranoflavone; Molecular docking; TOPOISOMERASE-I; ANTICANCER; INHIBITORS; TARGET;
D O I：
10.1007/s43450-022-00267-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Phytochemical investigation of Ficus benghalensis L., Moraceae, leaves revealed three known compounds, carpachromene, mucusoside, and 2-O-alpha-L-rhamnopyranosyl-(2R)-hydroxyhexacosanoate-beta-D-glucopyranosyl ester. Herein, the cytotoxic activity of the isolated compounds was measured against the HL60 cancer cell line. Our findings revealed that carpachromene exerted potent anti-proliferative activity. Also, this compound induced apoptosis and cell cycle arrest at the G2/M phase. Docking analysis revealed the potential interaction of carpachromene with topoisomerase I. This was confirmed by western blotting where carpachromene inhibited topoisomerase I protein expression. Additionally, carpachromene upregulated the expression of pro-apoptotic genes. In conclusion, F. benghalensis leaves exerted potent anti-proliferative activity against HL60 cancer cells.
引用
收藏
页码：527 / 536
页数：10
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