Chorioamnionitis - A complex pathophysiologic syndrome

被引:109
作者
Menon, R. [1 ,2 ,3 ]
Taylor, R. N. [2 ]
Fortunato, S. J. [3 ,4 ]
机构
[1] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Gynecol & Obstet, Atlanta, GA 30322 USA
[3] Centennial Womens Hosp, Perinatal Res Ctr, Nashville, TN USA
[4] Maternal Fetal Grp Pediat, Nashville, TN USA
关键词
Premature rupture of membranes; Prematurity; Fetal membranes; Preterm labor; Inflammation; Apoptosis; PRETERM PREMATURE RUPTURE; C-REACTIVE-PROTEIN; CORTICOTROPIN-RELEASING HORMONE; AMNIOTIC-FLUID INTERLEUKIN-6; FETAL INFLAMMATORY RESPONSE; NECROSIS-FACTOR-ALPHA; HISTOLOGIC CHORIOAMNIONITIS; CLINICAL-SIGNIFICANCE; BACTERIAL VAGINOSIS; GENETIC AMNIOCENTESIS;
D O I
10.1016/j.placenta.2009.11.012
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chorioamnionitis, inflammation of the amniochorionic membrane (feral membranes) is a very common disease but a complex syndrome associated with pregnancy It presents a clinical impasse due to lack of knowledge of specific etiologies associated with this condition making confident clinical interventions difficult. Recent reports provide insight into genetic, epigenetic, behavioral, psychosocial, molecular and pathophysiological factors that are associated with chorioamnionitis. However, a coordinated approach in understanding causality and lack of early indicators (clinical and biomarkers) has hampered gaining knowledge about the disease status preventing proper intervention Several reviews have provided in-depth analysis of the histologic and clinical evidence associated with chorioammonitis In this review. we provide a novel perspective on chorioamnionitis based on recent evidences from scientific literature on inflammation, apoptosis and genetics (C) 2009 Elsevier Ltd. All rights reserved
引用
收藏
页码:113 / 120
页数:8
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