Genomic organization of the OS-9 gene amplified in human sarcomas

被引：0
作者：
Kimura, Y
Nakazawa, M
Tsuchiya, N
Asakawa, S
Shimizu, N
Yamada, M
机构：
[1] YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI,KANAZAWA KU,YOKOHAMA,KANAGAWA 236,JAPAN
[2] KEIO UNIV,SCH MED,DEPT MOL BIOL,SHINJUKU KU,TOKYO 160,JAPAN
来源：
JOURNAL OF BIOCHEMISTRY | 1997年 / 122卷 / 06期
关键词：
human sarcomas; OS-9; gene; gene structure; 5' upstream region; transcription start sites;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The OS-9 gene is frequently amplified in human sarcomas, We isolated and characterized an OS-9 genomic DNA from a human BAC library, Sequencing of the genomic DNA showed that the gene spanned approximately 30.4 kbp and had 15 exons, The 1,010 bp sequence of the 5' upstream region was also determined, The potential binding-sequence motifs TATA and CCAAT for general transcription factors were found in the 5' upstream region, Primer extension analysis revealed two putative transcription start sites, The significance of the 5' upstream sequence in the ubiquitous expression of the OS-9 gene in various tissues and culture cells is discussed.
引用
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页码：1190 / 1195
页数：6
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