Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea

被引：49

作者：

Damre, AS ^{[1
]}

Gokhale, AB ^{[1
]}

Phadke, AS ^{[1
]}

Kulkarni, KR ^{[1
]}

Saraf, MN ^{[1
]}

机构：

[1] Bombay Coll Pharm, Dept Pharmacol, Bombay 400098, Maharashtra, India

来源：

FITOTERAPIA | 2003年 / 74卷 / 03期

关键词：

Tephrosia purpurea; flavonoids; immunomodulation activity;

D O I：

10.1016/S0367-326X(03)00042-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The flavonoid fraction of Tephrosia purpurea (FFTP) was studied for its effect on cellular and humoral functions and on macrophage phagocytosis in mice. Oral administration of FFTP (10-40 mg/kg) significantly inhibited sheep red blood cells (SRBC)-induced delayed-type hypersensitivity reactions. It also produced a significant, dose-related decrease in sheep erythrocyte-specific haemagglutination antibody titre. However, the fraction failed to show a significant change in the macrophage phagocytic activity. The results obtained indicate the ability of the flavonoidal fraction of T purpurea to modulate both the cell-mediated and the humoral components of the immune system. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：257 / 261

页数：5

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