Okadaic acid in New Zealand sponges: Detection by cytotoxicity, protein phosphatase inhibition and immunoassay techniques

被引：4
作者：
Perry, NB
Ellis, G
Blunt, JW
Haystead, TAJ
Lake, RJ
Munro, MHG
机构：
[1] Univ Otago, Plant Extracts Res Unit, Dunedin, New Zealand
[2] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand
[3] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA
[4] Inst Environm Sci & Res Ltd, Christchurch, New Zealand
来源：
NATURAL PRODUCT LETTERS | 1998年 / 11卷 / 04期
关键词：
okadaic acid; protein phosphatase; ELISA; immunoassay; marine sponge; cytotoxic;
D O I：
10.1080/10575639808044964
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using a combination of P388 cytotoxicity testing, protein phosphatase enzyme inhibition assays and an ELISA immunoassay, okadaic acid (1), the causative agent of diarrhetic shellfish poisoning (DSP), has been found in Raspalia agminata, and detected in two other species of New Zealand sponges.
引用
收藏
页码：305 / 312
页数：8
相关论文
共 24 条
  • [1] Bergquist P.R., 1970, NZ OCEANOGRAPHIC I M, V51
  • [2] REVERSE PHASE FLASH CHROMATOGRAPHY - A METHOD FOR THE RAPID PARTITIONING OF NATURAL PRODUCT EXTRACTS
    BLUNT, JW
    CALDER, VL
    FENWICK, GD
    LAKE, RJ
    MCCOMBS, JD
    MUNRO, MHG
    PERRY, NB
    [J]. JOURNAL OF NATURAL PRODUCTS, 1987, 50 (02): : 290 - 292
  • [3] COHEN P, 1989, J BIOL CHEM, V264, P21435
  • [4] MOTUPORIN, A POTENT PROTEIN PHOSPHATASE INHIBITOR ISOLATED FROM THE PAPUA-NEW-GUINEA SPONGE THEONELLA-SWINHOEI GRAY
    DESILVA, ED
    WILLIAMS, DE
    ANDERSEN, RJ
    KLIX, H
    HOLMES, CFB
    ALLEN, TM
    [J]. TETRAHEDRON LETTERS, 1992, 33 (12) : 1561 - 1564
  • [5] Isolation of calyculins, calyculinamides, and swinholide H from the New Zealand deep-water marine sponge Lamellomorpha strongylata
    Dumdei, EJ
    Blunt, JW
    Munro, MHG
    Pannell, LK
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (08) : 2636 - 2639
  • [6] SHALLOW ROCK-WALL BIOLOGICAL ASSOCIATIONS OF SOME SOUTHERN FIORDS OF NEW-ZEALAND
    GRANGE, KR
    SINGLETON, RJ
    RICHARDSON, JR
    HILL, PJ
    MAIN, WD
    [J]. NEW ZEALAND JOURNAL OF ZOOLOGY, 1981, 8 (02) : 209 - 227
  • [7] EFFECTS OF THE TUMOR PROMOTER OKADAIC ACID ON INTRACELLULAR PROTEIN-PHOSPHORYLATION AND METABOLISM
    HAYSTEAD, TAJ
    SIM, ATR
    CARLING, D
    HONNOR, RC
    TSUKITANI, Y
    COHEN, P
    HARDIE, DG
    [J]. NATURE, 1989, 337 (6202) : 78 - 81
  • [8] NEW DIOL ESTERS ISOLATED FROM CULTURES OF THE DINOFLAGELLATES PROROCENTRUM-LIMA AND PROROCENTRUM-CONCAVUM
    HU, TM
    MARR, J
    DEFREITAS, ASW
    QUILLIAM, MA
    WALTER, JA
    WRIGHT, JLC
    PLEASANCE, S
    [J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (11): : 1631 - 1637
  • [9] ISOLATION OF A NEW DIARRHETIC SHELLFISH POISON FROM IRISH MUSSELS
    HU, TM
    DOYLE, J
    JACKSON, D
    MARR, J
    NIXON, E
    PLEASANCE, S
    QUILLIAM, MA
    WALTER, JA
    WRIGHT, JLC
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (01) : 39 - 41
  • [10] Two new water-soluble DSP toxin derivatives from the dinoflagellate Prorocentrum maculosum: Possible storage and excretion products
    Hu, TM
    Curtis, JM
    Walter, JA
    McLachlan, JL
    Wright, JLC
    [J]. TETRAHEDRON LETTERS, 1995, 36 (51) : 9273 - 9276
123