Okadaic acid in New Zealand sponges: Detection by cytotoxicity, protein phosphatase inhibition and immunoassay techniques

被引：4

作者：

Perry, NB

Ellis, G

Blunt, JW

Haystead, TAJ

Lake, RJ

Munro, MHG

机构：

[1] Univ Otago, Plant Extracts Res Unit, Dunedin, New Zealand

[2] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

[3] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA

[4] Inst Environm Sci & Res Ltd, Christchurch, New Zealand

来源：

NATURAL PRODUCT LETTERS | 1998年 / 11卷 / 04期

关键词：

okadaic acid; protein phosphatase; ELISA; immunoassay; marine sponge; cytotoxic;

D O I：

10.1080/10575639808044964

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a combination of P388 cytotoxicity testing, protein phosphatase enzyme inhibition assays and an ELISA immunoassay, okadaic acid (1), the causative agent of diarrhetic shellfish poisoning (DSP), has been found in Raspalia agminata, and detected in two other species of New Zealand sponges.

引用

收藏

页码：305 / 312

页数：8

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