Accuracy of MRI criteria for dissemination in space for the diagnosis of multiple sclerosis in patients with clinically isolated syndromes

被引:11
作者
Diaz-Sanchez, Maria [1 ,2 ]
Mayra Gomez-Moreno, S. [2 ]
Asuncion Morales-Otal, M. [2 ]
Ramos-Gonzalez, Ana [3 ]
Benito-Leon, Julian [2 ,4 ]
机构
[1] Univ Hosp Virgen del Rocio, Dept Neurol, Seville 41013, Spain
[2] Univ Hosp Doce de Octubre, Dept Neurol, Madrid, Spain
[3] Univ Hosp Doce de Octubre, Dept Neuroradiol, Madrid, Spain
[4] CIBERNED, Madrid, Spain
关键词
clinically isolated syndromes; multiple sclerosis; MRI; diagnostic criteria; ISOLATED DEMYELINATING SYNDROMES; PREDICT CONVERSION; MCDONALD CRITERIA; IMAGING CRITERIA; DEFINITE; MS; GUIDELINES;
D O I
10.1177/1352458510362996
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The MRI Barkhof-Tintore criteria have proved to be highly specific for predicting conversion to clinically definite multiple sclerosis in patients with clinically isolated syndromes (CIS), but lacked an optimal sensitivity. In order to improve the accuracy of early multiple sclerosis diagnosis, new imaging criteria have been proposed by Swanton et al. We aimed to evaluate the accuracy of both MRI criteria for dissemination in space to predict conversion from CIS to clinically definite multiple sclerosis. We studied 79 CIS patients with baseline MRI performed within the first 3 months after onset. The sensitivity and specificity of both MRI criteria to predict conversion to clinically definite multiple sclerosis were analysed. The time to develop clinically definite multiple sclerosis from CIS onset, according to each imaging criteria, was studied by Kaplan-Meier survival curves. The overall conversion rate was 75.7% with a median follow-up of 57 months. Barkhof-Tintore's criteria showed a sensitivity of 71.9% and a specificity of 77.2%. Swanton's criteria had a sensitivity of 91.2% and a specificity of 68.1%. Both MRI criteria identified CIS patients with higher risk and faster conversion to clinically definite multiple sclerosis. Swanton's criteria are simpler and more sensitive than Barkhof-Tintore's criteria, with a slight decrease in specificity. These results reinforce their use in multiple sclerosis diagnosis.
引用
收藏
页码:576 / 580
页数:5
相关论文
共 21 条
[1]   Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis [J].
Barkhof, F ;
Filippi, M ;
Miller, DH ;
Scheltens, P ;
Campi, A ;
Polman, CH ;
Comi, G ;
Ader, HJ ;
Losseff, N ;
Valk, J .
BRAIN, 1997, 120 :2059-2069
[2]   Effect of early interferon treatment on conversion to definite multiple sclerosis:: a randomised study [J].
Comi, G ;
Filippi, M ;
Barkhof, F ;
Durelli, L ;
Edan, G ;
Fernández, O ;
Hartung, HP ;
Seeldrayers, P ;
Sorensen, PS ;
Rovaris, M ;
Martinelli, V ;
Hommes, OR .
LANCET, 2001, 357 (9268) :1576-1582
[3]   Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis [J].
Dalton, CM ;
Brex, PA ;
Miszkiel, KA ;
Hickman, SJ ;
MacManus, DG ;
Plant, GT ;
Thompson, AJ ;
Miller, DH .
ANNALS OF NEUROLOGY, 2002, 52 (01) :47-53
[4]   Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. [J].
Jacobs, LD ;
Beck, RW ;
Simon, JH ;
Kinkel, RP ;
Brownscheidle, CM ;
Murray, TJ ;
Simonian, NA ;
Slasor, PJ ;
Sandrock, AW .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (13) :898-904
[5]   Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes [J].
Kappos, L. ;
Polman, C. H. ;
Freedman, M. S. ;
Edan, G. ;
Hartung, H. P. ;
Miller, D. H. ;
Montalban, X. ;
Barkhof, F. ;
Bauer, L. ;
Jakobs, P. ;
Pohl, C. ;
Sandbrink, R. .
NEUROLOGY, 2006, 67 (07) :1242-1249
[6]   MRI criteria for dissemination in space in patients with clinically isolated syndromes:: a multicentre follow-up study [J].
Korteweg, T ;
Tintoré, M ;
Uitdehoog, B ;
Rovira, A ;
Frederiksen, J ;
Miller, D ;
Fernando, K ;
Filippi, M ;
Agosta, F ;
Rocca, M ;
Fazekas, F ;
Enzinger, C ;
Matthews, P ;
Parry, A ;
Polman, C ;
Montalban, X ;
Barkhof, F .
LANCET NEUROLOGY, 2006, 5 (03) :221-227
[7]  
KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444
[8]   Prediction of conversion from clinically isolated syndrome to clinically definite multiple sclerosis according to baseline MRI findings: comparison of revised McDonald criteria and Swanton modified criteria [J].
Lo, C-P ;
Kao, H-W ;
Chen, S-Y ;
Hsueh, C-J ;
Lin, W-C ;
Hsu, W-L ;
Wu, D-K ;
Liu, G-C .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (10) :1107-1109
[9]   Clinically isolated syndromes -: A new oligoclonal band test accurately predicts conversion to MS [J].
Masjuan, J ;
Alvarez-Cermeño, JC ;
García-Barragán, N ;
Díaz-Sánchez, M ;
Espiño, M ;
Sádaba, MC ;
González-Porqué, P ;
San Millán, JM ;
Villar, LM .
NEUROLOGY, 2006, 66 (04) :576-578
[10]   Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis [J].
McDonald, WI ;
Compston, A ;
Edan, G ;
Goodkin, D ;
Hartung, HP ;
Lublin, FD ;
McFarland, HF ;
Paty, DW ;
Polman, CH ;
Reingold, SC ;
Sandberg-Wollheim, M ;
Sibley, W ;
Thompson, AJ ;
van den Noort, S ;
Weinshenker, BY ;
Wolinsky, JS .
ANNALS OF NEUROLOGY, 2001, 50 (01) :121-127