Regulation of Mitochondrial ATP Production: Ca2+ Signaling and Quality Control

被引：219

作者：

Boyman, Liron ^{[1
,2
]}

Karbowski, Mariusz ^{[1
,3
]}

Lederer, W. Jonathan ^{[1
,2
]}

机构：

[1] Univ Maryland, Ctr Biomed Engn & Technol, Sch Med, Baltimore, MD 21201 USA

[2] Univ Maryland, Dept Physiol, Sch Med, Baltimore, MD 21201 USA

[3] Univ Maryland, Dept Biochem & Mol Biol, Sch Med, Baltimore, MD 21201 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 01期

基金：

美国国家卫生研究院;

关键词：

UBIQUITIN LIGASE MARCH5; ENDOPLASMIC-RETICULUM; MITOFUSIN; OXIDATIVE-PHOSPHORYLATION; RYANODINE RECEPTOR; CALCIUM UNIPORTER; OXYGEN-CONSUMPTION; MICE LACKING; MOUSE MODEL; BIOENERGETIC RESPONSES;

D O I：

10.1016/j.molmed.2019.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria and is dynamically regulated by Ca2+ levels in the mitochondrial matrix as well as by cytosolic ADP. We discuss mitochondrial Ca2+ signaling and its dysfunction which has recently been linked to cardiac pathologies including arrhythmia and heart failure. Similar dysfunction in other excitable and long-lived cells including neurons is associated with neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Central to this new understanding is crucial Ca2+ regulation of both mitochondrial quality control and ATP production. Mitochondria -associated membrane (MAM) signaling from the sarcoplasmic reticulum (SR) and the endoplasmic reticulum (ER) to mitochondria is discussed. We propose future research directions that emphasize a need to define quantitatively the physiological roles of MAMs, as well as mitochondrial quality control and ATP production.

引用

页码：21 / 39

页数：19

共 214 条

[31] SPATIAL NONUNIFORMITIES IN [CA2+](I) DURING EXCITATION-CONTRACTION COUPLING IN CARDIAC MYOCYTES [J].