UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication

被引：221

作者：

Biasin, Mara ^{[1
]}

Bianco, Andrea ^{[2
]}

Pareschi, Giovanni ^{[2
]}

Cavalleri, Adalberto ^{[3
]}

Cavatorta, Claudia ^{[3
]}

Fenizia, Claudio ^{[1
,6
]}

Galli, Paola ^{[2
]}

Lessio, Luigi ^{[4
]}

Lualdi, Manuela ^{[5
]}

Tombetti, Enrico ^{[1
]}

Ambrosi, Alessandro ^{[6
]}

Redaelli, Edoardo Maria Alberto ^{[2
]}

Saulle, Irma ^{[1
,7
]}

Trabattoni, Daria ^{[1
]}

Zanutta, Alessio ^{[2
]}

Clerici, Mario ^{[7
,8
]}

机构：

[1] Univ Milan, Dept Biomed & Clin Sci L Sacco, Milan, Italy

[2] Italian Natl Inst Astrophys INAF, Brera Astron Observ, Merate, Italy

[3] IRCCS Fdn, Epidemiol & Prevent Unit, Ist Nazl Tumori, Milan, Italy

[4] Italian Natl Inst Astrophys INAF, Padova Astron Observ, Padua, Italy

[5] IRCCS Fdn, Dept Imaging Diagnost & Radioterapy, Ist Nazl Tumori, Milan, Italy

[6] Univ Life & Hlth San Raffaele, Milan, Italy

[7] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[8] IRCCS Fdn, Don C Gnocchi Fdn, Milan, Italy

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

ULTRAVIOLET GERMICIDAL IRRADIATION; VIRAL-RNA; VIRUSES; CORONAVIRUS; MECHANISMS; LIGHT; QPCR;

D O I：

10.1038/s41598-021-85425-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm(2) was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm(2). These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.

引用

页数：7

共 32 条

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