Synthesis and intracellular drug delivery applications of hyperbranched polymers functionalized β-cyclodextrin

被引：14

作者：

Wan, Weimin ^{[1
]}

Ouyang, Hui ^{[1
]}

Jiang, Zhihui ^{[1
]}

Cui, Yushun ^{[1
]}

Li, Junmao ^{[1
,2
]}

He, Mingzhen ^{[1
,2
]}

Yang, Shilin ^{[2
]}

Zhang, Xiaoyong ^{[3
]}

Feng, Yulin ^{[1
,2
]}

Wei, Yen ^{[4
,5
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, State Key Lab Innovat Drug & Efficient Energy Sav, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Univ, Dept Chem, 999 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China

[4] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[5] Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China

来源：

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS | 2021年 / 42卷

关键词：

Hyperbranched polymers; beta-Cyclodextrin; Intracellular drug delivery; Dendritic structure; pH-controlled release; Cancer treatment; MESOPOROUS SILICA NANOPARTICLES; AGGREGATION-INDUCED EMISSION; WALLED CARBON NANOTUBES; MULTICOMPONENT REACTION; FACILE FABRICATION; GRAPHENE OXIDE; POLYMERIZATION; NANOCARRIERS; DOXORUBICIN; DERIVATIVES;

D O I：

10.1016/j.colcom.2021.100425

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hyperbranched polymers have been extensively investigated for different application for their specific structure, functional groups and biocompatibility. Herein, we reported synthesis of hyperbranched polymers (named as beta-CD-HPG-EBA-HH) using beta-cyclodextrin (beta-CD) as the precursor through anionic ring-opening polymerization. The hydrazide groups were further introduced onto functionalized beta-CD, that could form dynamic hydrazone bonds with anticancer agent epirubicin (EPI). After mixing beta-CD-HPG-EBA-HH with EPI, drug-containing polymeric nanoparticles with excellent water dispersibility can be obtained. The drug loading efficiency could reach to about 42.5% and the drug release shows pH dependent behavior. Biological assays indicated that beta-CD-HPGEBA-HH-EPI complexes could enter into cells via endocytosis and maintained desirable antitumor effects. Based on this method, many other functional materials could also be fabricated and potentially applied in various biomedical fields because of their unique dendritic structure of hyperbranched polymers and inclusion properties of beta-CD.

引用

页数：7

共 51 条

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