An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs

被引：129
作者：
Inoue, T
Chen, GH
Nakamae, K
Hoffman, AS
机构：
[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA
[2] Kobe Univ, Fac Engn, Kobe, Hyogo 657, Japan
来源：
JOURNAL OF CONTROLLED RELEASE | 1998年 / 51卷 / 2-3期
关键词：
block copolymer; micelle; oligo(methyl methacrylate); poly(acrylic acid);
D O I：
10.1016/S0168-3659(97)00172-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An AB block copolymer of oligo(methyl methacrylate) (oMMA) and poly(acrylic acid) (PAAc) has been synthesized. The block copolymer forms micelles in an aqueous medium, as confirmed by a fluorescence probe technique using pyrene. Doxorubicin hydrochloride was incorporated into the micelle and the release profile of doxorubicin hydrochloride was investigated. Slow and prolonged release of doxorubicin hydrochloride from the micelle was observed. The AB block copolymer micelle can be useful for prolonged mucosal drug delivery of hydrophobic drugs. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：221 / 229
页数：9
相关论文
共 30 条
[1]   SELF-AGGREGATES OF HYDROPHOBIC POLYSACCHARIDE DERIVATIVES [J].
AKIYOSHI, K ;
YAMAGUCHI, S ;
SUNAMOTO, J .
CHEMISTRY LETTERS, 1991, (07) :1263-1266
[2]   SELF-AGGREGATES OF HYDROPHOBIZED POLYSACCHARIDES IN WATER - FORMATION AND CHARACTERISTICS OF NANOPARTICLES [J].
AKIYOSHI, K ;
DEGUCHI, S ;
MORIGUCHI, N ;
YAMAGUCHI, S ;
SUNAMOTO, J .
MACROMOLECULES, 1993, 26 (12) :3062-3068
[3]   SELF-ASSEMBLY OF HYDROPHOBIZED POLYSACCHARIDE - STRUCTURE OF HYDROGEL NANOPARTICLE AND COMPLEXATION WITH ORGANIC-COMPOUNDS [J].
AKIYOSHI, K ;
DEGUCHI, S ;
TAJIMA, H ;
NISHIKAWA, T ;
SUNAMOTO, J .
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1995, 71 (01) :15-19
[4]   WATERSOLUBLE POLYMERS IN MEDICINE [J].
BADER, H ;
RINGSDORF, H ;
SCHMIDT, B .
ANGEWANDTE MAKROMOLEKULARE CHEMIE, 1984, 123 (AUG) :457-485
[5]   GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH [J].
CHEN, GH ;
HOFFMAN, AS .
NATURE, 1995, 373 (6509) :49-52
[6]   A hydrophobically-modified bioadhesive polyelectrolyte hydrogel for drug delivery [J].
Inoue, T ;
Chen, GH ;
Nakamae, K ;
Hoffman, AS .
JOURNAL OF CONTROLLED RELEASE, 1997, 49 (2-3) :167-176
[7]  
INOUE T, 1995, P 7 INT S REC ADV DR, P147
[8]  
KALYANASUNDORAM K, 1988, J AM CHEM SOC, V99, P2039
[9]  
KATAOKA K, 1993, J CONTROL RELEASE, V24, P119
[10]   ENHANCED TUMOR ACCUMULATION AND PROLONGED CIRCULATION TIMES OF MICELLE-FORMING POLY(ETHYLENE OXIDE-ASPARTATE) BLOCK COPOLYMER-ADRIAMYCIN CONJUGATES [J].
KWON, G ;
SUWA, S ;
YOKOYAMA, M ;
OKANO, T ;
SAKURAI, Y ;
KATAOKA, K .
JOURNAL OF CONTROLLED RELEASE, 1994, 29 (1-2) :17-23
123