Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study

被引：7
作者：
Jelvehgaran, Pouya [1 ,2 ,3 ]
Alderliesten, Tanja [2 ]
Georgiou, Giota [2 ]
Meijer, Sybren L. [4 ]
Bloemen, Paul R. [1 ]
Kodach, Liudmila L. [4 ]
van Laarhoven, Hanneke W. M. [5 ,6 ]
Henegouwen, Mark I. van Berge [6 ,7 ]
Hulshof, Maarten C. C. M. [2 ]
Rasch, Coen R. N. [2 ]
van Leeuwen, Ton G. [1 ]
de Boer, Johannes F. [3 ]
de Bruin, Martijn [1 ,8 ]
van Herk, Marcel [1 ,9 ]
机构：
[1] Univ Amsterdam, Dept Biomed Engn & Phys, Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Dept Radiat Oncol, Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Inst Laser Life & Biophoton Amsterdam, Dept Phys & Astron, NL-1081 HV Amsterdam, Netherlands
[4] Univ Amsterdam, Amsterdam UMC, Dept Pathol, Amsterdam, Netherlands
[5] Univ Amsterdam, Amsterdam UMC, Dept Med Oncol, NL-1105 AZ Amsterdam, Netherlands
[6] Univ Amsterdam, Canc Ctr Amsterdam, NL-1105 AZ Amsterdam, Netherlands
[7] Univ Amsterdam, Amsterdam UMC, Dept Surg, NL-1105 AZ Amsterdam, Netherlands
[8] Univ Amsterdam, Amsterdam UMC, Dept Urol, NL-1105 AZ Amsterdam, Netherlands
[9] Univ Manchester, Manchester Acad Hlth Sci Ctr, Sch Med Sci, Div Canc Sci,Manchester Canc Res Ctr,Fac Biol Med, Manchester M13 9PL, Lancs, England
来源：
BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 09期
关键词：
POSITRON-EMISSION-TOMOGRAPHY; VOLUMETRIC LASER ENDOMICROSCOPY; SQUAMOUS-CELL CARCINOMA; ESOPHAGEAL CANCER; IN-VIVO; PREOPERATIVE CHEMORADIOTHERAPY; BARRETTS-ESOPHAGUS; JUNCTIONAL CANCER; TUMOR-REGRESSION; PET-CT;
D O I：
10.1364/BOE.9.004196
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
引用
收藏
页码：4196 / 4216
页数：21
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