Human mast cells express intracellular TRAIL

被引：8

作者：

Berent-Maoz, Beata ^{[1
]}

Salemi, Souzan ^{[2
]}

Mankuta, David ^{[3
]}

Simon, Hans-Uwe ^{[2
]}

Levi-Schaffer, Francesca ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res,Dept Pharmacol & Expt Therapeut, IL-91120 Jerusalem, Israel

[2] Univ Bern, Inst Pharmacol, Bern, Switzerland

[3] Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91120 Jerusalem, Israel

来源：

CELLULAR IMMUNOLOGY | 2010年 / 262卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Mast cells; TRAIL; Apoptosis; Cell activation; APOPTOSIS-INDUCING LIGAND; HUMAN T-CELLS; ACTIVATION; MICROVESICLES; SURFACE; DEATH; LINE; FASL;

D O I：

10.1016/j.cellimm.2010.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently we demonstrated that human mast cells (MC) express functional TRAIL death receptors. Here we assessed the expression of TRAIL on both mRNA and protein level in cord blood derived MC (CBMC) and HMC-1. The TRAIL release either spontaneous or induced by LPS, IFN-gamma and IgE-dependent activation, was evaluated as well. The protein location was restricted to the intracellular compartment in CBMC, but not in HMC-1. The intracellular TRAIL was not localized inside the granules. The treatment with IFN-gamma and LPS up-regulated intracellular TRAIL expression in CBMC, but did not induce its release. These in vitro data show that human MC can produce and express intracellular TRAIL whose location could not be altered by different stimuli. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：80 / 83

页数：4

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