A convenient synthesis and structural analysis of novel 4,5,6,7-tetrahydro-1H-indazoles

被引：4
|
作者：
Murugavel, K. [1 ]
Amirthaganesan, S. [2 ]
Mohan, R. T. Sabapathy [1 ,3 ]
机构：
[1] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamil Nadu, India
[2] Pukyong Natl Univ, Div Image & Informat Engn, Pusan 608739, South Korea
[3] Manonmaniyam Sundaranar Univ, Tirunelveli, Tamil Nadu, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2010年 / 46卷 / 03期
关键词：
cyclic beta-keto esters; 1H-indazole; tetrahydroindazole; HMBC; NOESY spectra;
D O I：
10.1007/s10593-010-0505-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new series of t-4-aryl-3,c-6-dihydroxy-6-methyl-4,5,6,7-tetrahydro-1H-indazole-r-5-carboxylic acid isopropyl esters has been synthesized by adopting a conventional method from cyclic beta-keto esters. H-1, C-13 NMR, and IR spectra for all the compounds were investigated. HMBC, HSQC, COSY, and NOESY spectra of the representative compounds were studied. The stereochemistry of a six-membered ring of the fused indazoles resembled that of keto esters. From the HMBC correlations the indazole structure was confirmed as 1H-indazole.
引用
收藏
页码：302 / 306
页数：5
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